Welcome to AlHaj Abed Lab
We are interested in understanding how maternal and paternal chromosomes communicate using genome-wide sequencing approaches and super-resolution imaging. Our lab aims to provide a better understanding of the fundamental mechanisms governing homologous chromosome 3D structure in the nucleus and how that contributes to gene regulation.
Research Focus
Our research aims to understand the mechanisms of paternal and maternal chromosome communication by investigating parental chromosome organization and how it contributes to gene function.
i) How are the different layers of organization formed and maintained during transcriptional switches and development, ii) what are the major factors and dynamics facilitating these changes, and iii) how can we apply these tools to understand other concepts of genome organization in healthy and disease states.
Structure & Function
What is the contribution of chromosome structure i) at the gene regulatory level, and ii) within tissue-specific contexts?
Mechanism & Dynamics
i) What are the major driving factors of pairing events?
ii) What are the step-by-step events leading to trans-homolog contacts?
Applications